Study the material safety data sheets for the hazards of the chemical, learn the instructions on handling, storage and the emergency measures in case of accident take our free online course to learn how to to properly apply and use your msds. The goal of this study was to evaluate the effects of several superdisintegrants on disintegration time. Polyplasdone xl 10 and polyplasdone inf 10, which are differentiated by particle size to give optimal formulation flexibility and meet the varied demands of the pharmaceutical industry. Polyplasdone xl10 exhibits a similar particle size as kollidon clf. It is optimized for singleuse, either on its own, or in conjunction with other stabilizers, offering highly effective means of preventing nonbiological haze in all types of beer. Res vol 01 issue 03 jul sep 2011 original article formulation and evaluation of delayed release pellets of rabeprazole sodium muthukumaran m,senthil kumar k l, ratnam b c. Due to porous particle morphology, it acts as super disintegrants, providing rapid disintegration to. Due to porous particle morphology, it acts as super disintegrants, providing rapid disintegration to denturecleaning tablets. Polyplasdone xl10 complexed with stabilized hydrogen peroxide. We produce excipients and active ingredients of outstanding quality and performance.
The mean particle sizes of clpvp in the cl, xl, xl10 and inf10 grades were 154. New oral solid dosage form for furosemide oral administration. Strawberry and cocoa flavors were purchased from quest international india ltd. Effect of compression force on hardness of ir ranitidine hcl tablets. It is commonly used as a disintegrant at a concentration ranging from 25% in solid dosage forms 2733. The monomeric unit may include a polar imide group, four nonpolar methylene groups, and a nonpolar methane group. Jul 14, 2015 it was discovered that the yield and other pellet properties were unacceptable at drug levels higher than 60%. Polyplasdone inf 10, with its relatively higher surface area. Meltinmouth pellets of fexofenadine hydrochloride using. All reagents and solvents used in the study were of analytical grade. Polyplasdones are used as disintegrants and dissolution agents for solid oral dosage forms in pharmaceuticals, and are even effective for poorly soluble dosage forms. Polyplasdone xl10 by ashland specialty chemical acts as a rheology modifier and tablet disintegrant.
Polyplastol 10, based on polyester molecule, is a product mainly studied for special polymers. Research article dissolution enhancement of carvedilol by. Jp2011195518a crospovidone and crospovidonecontaining. A crosslinked pvp, this, nonionic, waterinsoluble but swellable homopolymer is available in several grades xl, xl 10 differentiated by particle size. Kollidon clsf, which is reported to have a particle size similar to that of polyplasdone xl10 and inf10 20, failed as an extrusionspheronization aid. Among the variety of directly compressible super disintegrants available, sodium starch glycolate explotab, polyplasdoneinf10, polyplasdonexl, polyplasdonexl10, and hydroxypropyl cellulose lowsubstituted lhpclh21 were chosen, examined, and submitted to some compression attempts. Polyplasdone inf 10 225 150 375 polyplasdone xl 10 225 150 375 sugar spheres 660 660 660 660 660 660 talc 100 100 100 100 100 100 table 3. Crospovidone provides rapid disintegration and dissolution to oral solid dosage forms. Rabeprazole sodium core pellets ingredients formulations quantities in gms f2 f3 f4 f5 f6 285 sodium carbonate 150 225 150 225 0 0 hydroxy propyl methyl cellulose 80 80 80 80 80 80 polyplasdone inf 10 225 150 375 polyplasdone xl 10 225 150 375 sugar spheres 660 660 660 660 660 660. This class of polymer is well experimented with a wide range of drugs for improved performance and increased dissolution profile and are commercially available as polyplasdone xl, polyplasdone xl10, and polyplasdone inf10, based on the. Utility of polyplasdone crospovidone as a tablet binder. Polyplasdone inf10 polymer has the finest average particle size 510 p of the polyplasdone grades and is a highly adsorptive material. For local tollfree numbers, please look at section 1 of the country sds. Flush victims eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center.
It was discovered that the yield and other pellet properties were unacceptable at drug levels higher than 60%. Good compressibility supplied as freeflowing white powders, polyplasdone crospovidones are easy to handle during direct compression, as well as wet and drygranulation tablet manufacturing processes. First check the victim for contact lenses and remove if present. It is a nonionic, waterinsoluble but swellable crosslinked pvp homopolymer. Determination of threshold concentration of paracetamol. To provide crospovidone without causing a poor appearance even on absorbing moisture in the case of being incorporated in tablets, and also crospovidonecontaining tablets without forming the poor appearance by forming projected materials even if the tablets absorb moisture. Polyplasdone inf10 by ashland specialty chemical acts as a rheology modifier and tablet disintegrant. Three grades of crospovidone, namely polyplasdone xl, xl10, and inf10 in decreasing order of particle size, allowed the investigation of the particle size effects on water uptake and distribution, 14, and each of these has been a component in placebo pellets produced by extrusionspheronization. The minimum concentration among a range of dilutions of a. Kollidon clsf, which is reported to have a particle size similar to that of polyplasdone xl10 and inf10, failed as an extrusionspheronization aid, whereas a micronized particle grade, kollidon clm, was. Jul 12, 2012 this class of polymer is well experimented with a wide range of drugs for improved performance and increased dissolution profile and are commercially available as polyplasdone xl, polyplasdone xl 10, and polyplasdone inf 10, based on the particle size, sold by international specialty products isp.
Then it was compressed into tablets using 12mm punches on a rotary tablet machine. Polyplasdone of different particle size was used to study the sorption, desorption, and distribution of water, and to seek evidence that larger particles can internalize water. Sky67ka15uc polyplasdone inf10 sk67yvruhsv polyplasdone xl skgwgdz7dix polyplasdone xl10 rabbi eliyahu shuman director of supervision effective through 12312016 january 25, 2016 ashland specialty ingredients 455 n. Polyplasdone inf 10 polymers has the finest average particle size 510 of the. Calorimetric study of the effect of polyplasdone particle size on its uptake and distribution of water. Formulation and evaluation of cefetamet pivoxil hydrochloride.
To make squares disappear and save space for other squares you have to assemble english words left, right, up, down from the falling squares. Polyplastol 10 gives very good lubrication result in butyl rubber and other halogenated polymers as well. Dissolution enhancement of carvedilol by using surfactant as a. Results for heavy metals are based on increased interval testing every 30th lot tested. Polyplasdone xl and polyplasdone xl 10 are primarily superdisintegrants for solid dosage forms. The study showed that the tablets of polyplasdone xl and polyplasdone xl10 had a shorter disintegration time than the corresponding tablet with croscarmellose sodium and sodium starch glycolate. Application of nilvadipine solid dispersion to tablet. The mass is then dried and passed through the 25 mesh sieve. Quyen schwing, marvin davis, divya tewari, thomas durig ashland specialty ingredients, wilmington, delaware 19808, usa. Acdisol and primojel are significantly finer than kollidon cl and polyplasdone xl but coarser than the other disintegrants particle size was measured on a mastersizer, malvern instruments 3 see table i.
Moisture sorption and desorption isotherms at 25 c at 5% intervals from 0 to 95% relative humidity rh. Complying with usp, european and japanese pharmacopeia specifications for crospovidone, polyplasdone polymer act as tablet disintegrants. Polyplasdone xl 10 exhibits a similar particle size as kollidon clf. Polyplasdone xl 10 crospovidone particles are smaller, but also porous and granular. Polyplasdone inf10 ashland specialty chemical datasheet.
Polyplasdone xl chemical information, properties, structures, articles, patents and more chemical data. Utility of polyplasdone crospovidone as a superdisintegrant. Polyplasdone xl msds download sevron safety software. India import data of 39059990 import export data of 60. Polyplasdone xl10 and polyplasdone inf10, which are differentiated by particle size to give optimal formulation flexibility and meet the varied demands of the pharmaceutical industry. Polyclar 10 other names pvpp, polyvinylpolypyrrolidone, crosslinked polyvinylpyrrolidone description polyclar 10 is a highly effective 100% pvpp beer stabilizer. A crosslinked pvp, this, nonionic, waterinsoluble but swellable homopolymer is available in several grades xl, xl10 differentiated by particle size. Plasdone k 2932 chemical information, properties, structures, articles, patents and more chemical data. Polyplasdone grades and is highly adsorptive material. Polyplasdone inf10, with its relatively higher surface area.
Polyplasdone crospovidone superdisintegrants are synthetic, insoluble, but rapidly swellable, crosslinked homopolymers of nvinyl2pyrrolidone. Pdf meltinmouth pellets of fexofenadine hydrochloride using. Extragranular polyplasdone inf 10, collidal silicon dioxide and magnesium stearate is sifted through 60 mesh sieve and mixed with the dried granules. Polyclar 10 offers a very effective means of preventing nonbiological haze in all types of beer. The high surface area combined with unique chemistry results. View detailed import data, price, monthly trends, major importing countries, major ports of polyplasdone xl import data and price of polyplasdone xl zauba skip to main content.
Polyplasdone xl 10 complexed with stabilized hydrogen peroxide. Polyplasdone xl and polyplasdone xl10 are primarily superdisintegrants for solid dosage forms. Jun 08, 2017 several specific types of disintegrant are suitable for use in the formulations described herein. Isp produces its ultrapure grades of crospovidone polyplasdone ultra and ultra10 at a new facility in texas city, texas, which is also one of two sites where the company manufactures its standard pharmaceutical grades of crospovidone polyplasdone xl and polyplasdone xl10. Flush victims eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a. Kollidon clsf, which is reported to have a particle size similar to that of polyplasdone xl 10 and inf 10, failed as an extrusionspheronization aid, whereas a micronized particle grade, kollidon clm, was. Sky67ka15uc polyplasdone inf 10 sk67yvruhsv polyplasdone xl skgwgdz7dix polyplasdone xl 10 rabbi eliyahu shuman director of supervision effective through 12312016 january 25, 2016 ashland specialty ingredients 455 n. It actually guarantees an intimate incorporation and a good lubrication of acrylic polymers, such as for hydrogenated polymers and fluoro elastomers. Polyplasdone xl 10 was recommended as suitable disintegrants for the preparation of direct compression melt in mouth tablets of montelukast sodium. This is a reversible physical complexation without the formation of covalent chemical bonds.
It is optimized for singleuse, either on its own, or in conjunction with other stabilizers. It provides rapid disintegration, smooth mouthfeel and high tablet breaking force with low friability. The availability of a sds for a particular country or region does not guarantee that the product associated with that sds is available for sale in that country or region. Polyplasdone xl 10 by ashland specialty chemical acts as a rheology modifier and tablet disintegrant. Polyplasdone xl10 crospovidone is well suited for orally disintegrating and chewable tablet formulations. For example, any grade of crospovidone can be used, including for example crospovidone xl10, and includes members selected from the group consisting of kollidon cl, polyplasdone xl, kollidon clm, polyplasdone xl10, and polyplasdone inf10.
Pdf meltinmouth pellets of fexofenadine hydrochloride. Several specific types of disintegrant are suitable for use in the formulations described herein. Lettris is a curious tetrisclone game where all the bricks have the same square shape but different content. Above ingredients were taken in a polybag and mixed for 1 minute. Coprocessed excipient compositions isp investments inc. Isp produces its ultrapure grades of crospovidone polyplasdone ultra and ultra 10 at a new facility in texas city, texas, which is also one of two sites where the company manufactures its standard pharmaceutical grades of crospovidone polyplasdone xl and polyplasdone xl 10. Products typical average partical size polyplasdone xl 100 polyplasdone xl10 30 50 polyplasdone inf10 5 10 polyplasdone crospovidone is available in 3 particle sizes for optimum performance. A quality by experimental design approach to assess the. It is available in several grades differing mainly in the particle size, for example polyplasdone xl is a coarser grade while polyplasdone xl10 and polyplasdone inf10 are finer grades. Satapara page 6 designed domeshaped blister package using a robotcontrolled integrated tabletingpackaging system. Polyclar 10 is a highly effective 100% pvpp beer stabilizer. Polyplasdone crospovidone particles are granular and porous compared with other superdisintegrants. Contrasting the crospovidones functionality as excipients.
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